Theoretical Systems Biology

I initially studied Molecular Biosceinces in China, obtaining Bachelor’s (BSc) and Master’s (MSc) degrees at Nanjing University. In November 2008, I began my study at Imperial College as a PhD student working on membrane protein. I transferred to Prof Stumpf’s group in June 2009.

I am funded by Kwok Fundation for a 4-year PhD programme under the research topic “Modelling in Medicine, Life Sciences and Robotics”. My supervisors are Prof Michael Stumpf, Prof Martin Buck and Dr John Pinney. The aim of my research is to build and analyse models of biological networks, including metabolic network, protein interaction network and transcriptional regulatory network in Prokaryotic organism.

Evolution of Two-Component System: I am studying the evolutionary properties of two-component systems, including their distribution in the genome, evolutionary rates, sequences characteristics etc..
Modelling of ArcBA Two-Component System: I am using both deterministic and stochastic method to model ArcBA system trying to study its dimerization, phosphorelay and other dynamic.

GPU accelerated biochemical network simulation.
Zhou Y, Liepe J, Sheng X, Stumpf MP, Barnes C.
Bioinformatics. 2011 Jan 11

Managing membrane stress: the phage shock protein (Psp) response, from molecular mechanisms to physiology.
Joly N, Engl C, Jovanovic G, Huvet M, Toni T, Sheng X, Stumpf MP, Buck M.
FEMS Microbiol Rev. 2010 Sep;34(5):797-827. Epub 2010 Jun 9.

Managing membrane stress: the phage shock protein (Psp) response, from molecular mechanisms to physiology.
Joly N, Engl C, Jovanovic G, Huvet M, Toni T, Sheng X, Stumpf MP, Buck M.
FEMS Microbiol Rev. 2010 Sep;34(5):797-827. Epub 2010 Jun 9.