Rowan Brackston

I am a post-doctoral researcher in the Theoretical Systems Biology group at Imperial College where I have worked since May 2017. The focus of my work is split between the development of insightful models for development and regulation of cells, and the computational methods needed for this analysis.

I originally studied Aerospace and Aerothermal Engineering at the University of Cambridge, specialising in fluid mechanics and feedback control systems and graduating with an MEng (distinction) in 2013. I obtained my PhD in experimental aerodynamics and flow control from the Department of Aeronautics at Imperial College in September 2017, working under the supervision of Professor Jonathan Morrison and Dr Andrew Wynn. The work in my PhD was focussed on the development of stochastic models and feedback control algorithms to modify the flow over automotive vehicles.

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The route to transcription initiation determines the mode of transcriptional bursting in E. coli
C Engl*, G Jovanovic*, RD Brackston*, I Kotta-Loizou, M Buck
Nature Communications, 11:2422, (2020)

Exactly solvable models of stochastic gene expression
L Ham, D Schnoerr, RD Brackston, MPH Stumpf
Journal of Chemical Physics, (2020), 152, 144106

Extrinsic noise and heavy-tailed laws in gene expression
L Ham*, RD Brackston*, MPH Stumpf
Physical Review Letters, (2020), 124(10), 108101

Molecular origins of transcriptional heterogeneity in diazotrophic K. oxytoca
T Bashir*, RD Brackston*, CJ Waite, I Kotta-Loizou, C Engl, M Buck, J Schumacher
bioRxiv, (2020)

Transition state characteristics during cell differentiation
RD Brackston*, E Lakatos*, MPH Stumpf
PLoS Computational Biology, (2018), 14(9): e1006405

Construction of quasi-potentials for stochastic dynamical systems: An optimization approach
RD Brackston, A Wynn, MPH Stumpf
Physical Review E, (2018), 98, 022136

Modelling and feedback control of vortex shedding for drag reduction of a turbulent bluff body wake
RD Brackston, A Wynn, JF Morrison
International Journal of Heat and Fluid Flow, (2018), 71(C), 127-136

Feedback control of three-dimensional bluff body wakes for efficient drag reduction
RD Brackston
PhD Thesis, Imperial College London, (2017)

Adaptive Base-Flaps Under Variable Cross-Wind
JMG de la Cruz, RD Brackston, JF Morrison
SAE Technical Paper, (2017), 2017-01-7000

Extremum seeking to control the amplitude and frequency of a pulsed jet for bluff body drag reduction
RD Brackston, A Wynn, JF Morrison
Experiments in Fluids, (2016), 57 (10), 159

Stochastic modelling and feedback control of bistability in a turbulent bluff body wake
RD Brackston, JM Garcia de la Cruz, A Wynn, G Rigas, JF Morrison
Journal of Fluid Mechanics, (2016), 802, 726-749

Diffusive dynamics and stochastic models of turbulent axisymmetric wakes
G Rigas, AS Morgans, RD Brackston, JF Morrison
Journal of Fluid Mechanics, (2015), 778, R2