Michał Komorowski
NOTE: Michal Komorowski Left the lab in 2011
Since November 2011 I hold a restablishment fellowship received from the Foundation for Polish Science and work in the Institute of Fundamental Technological Research of Polish Academy of Sciences in Warsaw, Poland. My new webpage can be found here here.
I was a postdoctoral researcher in the Theoretical System Biology Group since January 2010. My adventure with mathematical modelling, began relatively far from biology at the Warsaw School of Economics. Further interest in probability theory encouraged me to undertake studies in mathematics and I obtained MSc from the Faculty of Mathematics, Informatics and Mechanics at the University of Warsaw. Thanks to mathematical biology community there I got fascinated with molecular biology and regulation of gene expression, in particular. Linking interests in stochastic processes and biochemical reactions resulted in my PhD in Statistics received from Department of Statistics, University of Warwick.
At present I am interested in the following topics:
- Information geometry
- Optimal design of experiments
- Statistics of stochastic processes
- Modelling molecular regulation and signalling
Software
StochSens – matlab package for sensitivity analysis of stochastic chemical systems
Preprints
Decomposing Noise in Biochemical Signalling Systems Highlights the Role of Protein Degradation
Komorowski M, Miekisz J, Stumpf MP., Submitted. ArXiv
A Bayesian hierarchical diffusion model for estimating kinetic parameters and cell-to-cell variability
Woodcock D.J., Komorowski M., Finkenstadt B.F., Harper C.V., Davis J.R.E, White M.R.H and Rand D.A., Submitted. PDF
Publications
Woodcock DJ, Vance KW, Komorowski M, Koentges G, Finkenstädt B, Rand DA.
Bioinformatics. 2013 May 17. [Epub ahead of print]
- PMID:
- 23677939
- [PubMed - as supplied by publisher]
Decomposing noise in biochemical signaling systems highlights the role of protein degradation.
Komorowski M, Miękisz J, Stumpf MP.
Biophys J. 2013 Apr 16;104(8):1783-93. doi: 10.1016/j.bpj.2013.02.027.
- PMID:
- 23601325
- [PubMed - in process]
Maximizing the information content of experiments in systems biology.
Liepe J, Filippi S, Komorowski M, Stumpf MP.
PLoS Comput Biol. 2013 Jan;9(1):e1002888. doi: 10.1371/journal.pcbi.1002888. Epub 2013 Jan 31.
- PMID:
- 23382663
- [PubMed - in process]
Harrington HA, Komorowski M, Beguerisse-Díaz M, Ratto GM, Stumpf MP.
Phys Biol. 2012 Jun;9(3):036001. doi: 10.1088/1478-3975/9/3/036001. Epub 2012 May 3.
- PMID:
- 22551942
- [PubMed - indexed for MEDLINE]
StochSens–Matlab package for sensitivity analysis of stochastic chemical systems.
Komorowski M, Zurauskiene J, Stumpf MP.
Bioinformatics. 2012 Mar 1;28(5):731-3. doi: 10.1093/bioinformatics/btr714.
- PMID:
- 22378710
- [PubMed - indexed for MEDLINE]
Sensitivity, robustness, and identifiability in stochastic chemical kinetics models.
Komorowski M, Costa MJ, Rand DA, Stumpf MP.
Proc Natl Acad Sci U S A. 2011 May 24;108(21):8645-50. doi: 10.1073/pnas.1015814108. Epub 2011 May 6.
- PMID:
- 21551095
- [PubMed - indexed for MEDLINE]
Komorowski M, Finkenstädt B, Rand D.
Biophys J. 2010 Jun 16;98(12):2759-69. doi: 10.1016/j.bpj.2010.03.032.
- PMID:
- 20550887
- [PubMed - indexed for MEDLINE]
Bayesian inference of biochemical kinetic parameters using the linear noise approximation.
Komorowski M, Finkenstädt B, Harper CV, Rand DA.
BMC Bioinformatics. 2009 Oct 19;10:343. doi: 10.1186/1471-2105-10-343.
- PMID:
- 19840370
- [PubMed - indexed for MEDLINE]
Komorowski M, Miekisz J, Kierzek AM.
Biophys J. 2009 Jan;96(2):372-84. doi: 10.1016/j.bpj.2008.09.052.
- PMID:
- 19167290
- [PubMed - indexed for MEDLINE]
Reconstruction of transcriptional dynamics from gene reporter data using differential equations.
Finkenstädt B, Heron EA, Komorowski M, Edwards K, Tang S, Harper CV, Davis JR, White MR, Millar AJ, Rand DA.
Bioinformatics. 2008 Dec 15;24(24):2901-7. doi: 10.1093/bioinformatics/btn562. Epub 2008 Oct 30.
- PMID:
- 18974172
- [PubMed - indexed for MEDLINE]