Maxime Huvet
I have been post-doctoral researcher in the Theoretical System Biology group since March 2008.
I am currently working on biological network evolution and prediction. My main interests are understanding the rules that drive network evolution, the relationship between genomic evolution and network evolution and how genomic evolution properties, known interaction data and other types of information could be used to improve the prediction of biological networks.
Current projects :
- Characterization of the sequence evolution properties of the proteins involved in the Phage shock stress response system identified in Escherichia coli K12 MG1655.
- Prediction of protein-protein interactions in Candida glabrata and comparison with Saccharomyces cerevisiae.
- Development of new network and data visualization tools. One of the objectives is to improve the access and visualization of network related data to facilitate explorative studies.
I am currently employed as a Teaching Fellow. As a Teaching fellow I have been lecturing in the MSc of Bioinformatics and Theoretical Systems Biology and the MRes of Systems and Synthetic Biology of imperial College London and involved in the adminstration of the MSc of Bioinformatics and Theoretical Systems Biology.
Before this postion, I completed my PhD (Paris VII – Diderot University) on gene organization in human genome according to replication profile. I performed my PhD under the supervision of Claude Thermes in the “Centre de Genetique Moleculaire-CNRS”, Gif-sur-Yvette.
Publications:
P38 and JNK have opposing effects on persistence of in vivo leukocyte migration in zebrafish.
Taylor HB, Liepe J, Barthen C, Bugeon L, Huvet M, Kirk PD, Brown SB, Lamb JR, Stumpf MP, Dallman MJ.
Immunol Cell Biol. 2013 Jan;91(1):60-9. doi: 10.1038/icb.2012.57. Epub 2012 Nov 20.
- PMID:
- 23165607
- [PubMed - in process]
Evolutionary characteristics of bacterial two-component systems.
Sheng X, Huvet M, Pinney JW, Stumpf MP.
Adv Exp Med Biol. 2012;751:121-37. doi: 10.1007/978-1-4614-3567-9_6.
- PMID:
- 22821456
- [PubMed - indexed for MEDLINE]
Liepe J, Taylor H, Barnes CP, Huvet M, Bugeon L, Thorne T, Lamb JR, Dallman MJ, Stumpf MP.
Integr Biol (Camb). 2012 Mar;4(3):335-45. doi: 10.1039/c2ib00175f. Epub 2012 Feb 10.
- PMID:
- 22327539
- [PubMed - indexed for MEDLINE]
Toni T, Jovanovic G, Huvet M, Buck M, Stumpf MP.
BMC Syst Biol. 2011 May 12;5:69. doi: 10.1186/1752-0509-5-69.
- PMID:
- 21569396
- [PubMed - indexed for MEDLINE]
Replication-associated mutational asymmetry in the human genome.
Chen CL, Duquenne L, Audit B, Guilbaud G, Rappailles A, Baker A, Huvet M, d’Aubenton-Carafa Y, Hyrien O, Arneodo A, Thermes C.
Mol Biol Evol. 2011 Aug;28(8):2327-37. doi: 10.1093/molbev/msr056. Epub 2011 Mar 2.
- PMID:
- 21368316
- [PubMed - indexed for MEDLINE]
Thorne TW, Ho HL, Huvet M, Haynes K, Stumpf MP.
Fungal Genet Biol. 2011 May;48(5):504-11. doi: 10.1016/j.fgb.2010.12.005. Epub 2010 Dec 28.
- PMID:
- 21193057
- [PubMed - indexed for MEDLINE]
Huvet M, Toni T, Sheng X, Thorne T, Jovanovic G, Engl C, Buck M, Pinney JW, Stumpf MP.
Mol Biol Evol. 2011 Mar;28(3):1141-55. doi: 10.1093/molbev/msq301. Epub 2010 Nov 8.
- PMID:
- 21059793
- [PubMed - indexed for MEDLINE]
Joly N, Engl C, Jovanovic G, Huvet M, Toni T, Sheng X, Stumpf MP, Buck M.
FEMS Microbiol Rev. 2010 Sep;34(5):797-827. doi: 10.1111/j.1574-6976.2010.00240.x. Epub 2010 Jun 9. Review.
- PMID:
- 20636484
- [PubMed - indexed for MEDLINE]
Impact of replication timing on non-CpG and CpG substitution rates in mammalian genomes.
Chen CL, Rappailles A, Duquenne L, Huvet M, Guilbaud G, Farinelli L, Audit B, d’Aubenton-Carafa Y, Arneodo A, Hyrien O, Thermes C.
Genome Res. 2010 Apr;20(4):447-57. doi: 10.1101/gr.098947.109. Epub 2010 Jan 26.
- PMID:
- 20103589
- [PubMed - indexed for MEDLINE]
Model-based evolutionary analysis: the natural history of phage-shock stress response.
Huvet M, Toni T, Tan H, Jovanovic G, Engl C, Buck M, Stumpf MP.
Biochem Soc Trans. 2009 Aug;37(Pt 4):762-7. doi: 10.1042/BST0370762.
- PMID:
- 19614590
- [PubMed - indexed for MEDLINE]
DNA replication timing data corroborate in silico human replication origin predictions.
Audit B, Nicolay S, Huvet M, Touchon M, d’Aubenton-Carafa Y, Thermes C, Arneodo A.
Phys Rev Lett. 2007 Dec 14;99(24):248102. Epub 2007 Dec 12.
- PMID:
- 18233493
- [PubMed - indexed for MEDLINE]
Human gene organization driven by the coordination of replication and transcription.
Huvet M, Nicolay S, Touchon M, Audit B, d’Aubenton-Carafa Y, Arneodo A, Thermes C.
Genome Res. 2007 Sep;17(9):1278-85. Epub 2007 Aug 3.
- PMID:
- 17675363
- [PubMed - indexed for MEDLINE]
Alsmark CM, Frank AC, Karlberg EO, Legault BA, Ardell DH, Canbäck B, Eriksson AS, Näslund AK, Handley SA, Huvet M, La Scola B, Holmberg M, Andersson SG.
Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9716-21. Epub 2004 Jun 21.
- PMID:
- 15210978
- [PubMed - indexed for MEDLINE]
F1000 faculty evaluations:
- “Human gene organization driven by the coordination of replication and transcription”. FFa: 11 link
- “The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae.”. FFa: 6 link
Oral communication as invited speaker:
- Role of the replication on Human genome evolution and organisation. – GTGC-Lille 2008 (JOBIM workshop)
- Role of the replication on Human genome evolution and organisation. – ACFAS-Ottawa 2009
Oral communication with peer-reviewed abstract submission:
- Ancestral state inference and network evolution of a bacterial stress response system. MASAMB London 2009
- Replication and gene organization in human genome. ALPHY Montpellier 2007
- Human gene organization driven by the coordination of replication and transcription. 3R (Replication, Reparation, Recombination) 2007
Award “best oral presentaton” by the SFTG (Société Française de Toxicologie Génétique)
Posters:
- Protein interaction network variation between S. cerevisiae and C. glabrata. Hsueh-lui Ho, Maxime Huvet, Michael Stumpf, Ken Haynes. Yeast Genetics and Molecular Biology Meeting Vancouver 2010
- Protein interaction network variation between S. cerevisiae and C. glabrata. Hsueh-lui Ho, Maxime Huvet, Michael Stumpf, Ken Haynes. 10th ASM Conference on Candida and Candidiasis Miami 2010
- In vivo extraction of single cell dynamics of leukocytes in zebrafish. Juliane Liepe, Maxime Huvet, Harriet B Taylor, Laurence Bugeon, Jonathan Lamb, Michael PH Stumpf. VIZBI Heidelberg 2009
- Replication and evolution of the human genome. Lauranne Duquenne, Maxime Huvet, Chun-Long Chen, Lamia Zaghloul, Benjamin Audit, Yves d’Aubenton-Carafa, Alain Arneodo and Claude Thermes. JOBIM Lille 2008
- Study of the Alpha-proteobacteria ancestor chromosome organization. M. Huvet S. andersson. ECCB – JOBIM Paris 2003
- Influence of evolution on exceptional motifs frequency in DNA sequences. M. Huvet G. Nuel. JOBIM St Malo 2002
Selected Grand Funding:
March-July 2008 Wellcome Trust VIP award (£18,000) Comparative Systems Biology of the Phage-shock Protein Stress Response in Pathogenic Bacteria With Professor Michael Stumpf and collaborators – Imperial College London