In my project I am studying signalling processes that are related to the innate immune response. After an injury, parts of the immune system are activated, specific immune cell leave the blood vessels and migrate through the tissue to the side of the injury. I investigate the migration of these immune cells, more specifically macrophages and neutrophils, which are the first layer of defence of the immune system in humans. It is still not fully understood, which signals drive the cells towards the injury, how the cells migrate and what do the cells do once they reached the site of injury are open questions.
Maximizing the Information Content of Experiments in Systems Biology.
Liepe J, Filippi S, Komorowski M, Stumpf MPH
PLoS Comput Biol. 2013 Jan;9(1):e1002888. doi: 10.1371/journal.pcbi.1002888. Epub 2013 Jan 31.
p38 and JNK have opposing effects on persistence of in vivo leukocyte migration in zebrafish.
Taylor HB, Liepe J, Barthen C, Bugeon L, Huvet M, Kirk PD, Brown SB, Lamb JR, Stumpf MP, Dallman MJ
Immunol Cell Biol. 2013 Jan;91(1):60-9. doi: 10.1038/icb.2012.57. Epub 2012 Nov 20.
Calibrating spatio-temporal models of leukocyte dynamics against in vivo live-imaging data using approximate Bayesian computation.
Liepe J, Taylor H, Barnes CP, Huvet M, Bugeon L, Thorne T, Lamb JR, Dallman MJ, Stumpf MP.
Integr Biol (Camb). 2012 Mar;4(3):335-45. doi: 10.1039/c2ib00175f. Epub 2012 Feb 10.
GPU accelerated biochemical network simulation.
Zhou Y, Liepe J, Sheng X, Stumpf MP, Barnes C.
Bioinformatics. 2011 Mar 15;27(6):874-6. doi: 10.1093/bioinformatics/btr015. Epub 2011 Jan 11.
ABC-SysBio–approximate Bayesian computation in Python with GPU support.
Liepe J, Barnes C, Cule E, Erguler K, Kirk P, Toni T, Stumpf MP.
Bioinformatics. 2010 Jul 15;26(14):1797-9. doi: 10.1093/bioinformatics/btq278.
The 20S proteasome splicing activity discovered by SpliceMet.
Liepe J, Mishto M, Textoris-Taube K, Janek K, Keller C, Henklein P, Kloetzel PM, Zaikin A.
PLoS Comput Biol. 2010 Jun 24;6(6):e1000830. doi: 10.1371/journal.pcbi.1000830.
Peer Reviewed Conference Proceedings
Microtubule tracking from stochastic optical reconstruction microscopy images.
J. Liepe, F. Felizzi, A. Pernus and M. Hanulova
Proceedings of the 8th WCSB, 2011
Variety of dynamical regimes in a population of coupled synthetic genetic oscillators.
A. Koseska, A. Zaikin, J. Liepe, and J. Kurths
Proceedings of the 3rd International Conference “Physics and Control” (PhysCon), 2007
ABC-SysBio : A tool for parameter inference and model selection.
Inference of signalling pathway models.
T. Toni, J. Liepe and M. Stumpf.
Handbook of Statistical Systems Biology, Wiley, 2011
“Method for identification of proteasome generated spliced peptides”. 2010,
Application number: EP10075087.6. Application date: 25.02.2010. Applicant: Charité – Berlin.
“Bayesian experimental design to probe cellular decision making processes”. 2012,
MASAMB (Workshop on Mathematical & Statistical Aspects of Molecular Biology),
“Calibrating multi-scale models of macrophage dynamics”. 2011,
PICA (Physics of Immunity: Complexity Approach),
“Quantitative imaging reveals p38 MAP kinase mediated chemotactic variability in leukocytes”. 2010,
MASAMB (Mathematical and Statistical Aspects of Molecular Biology),
University of Warwick, UK.
EMBO Workshop on Visualizing Biological Data, 2010
International Symposium for Topical Problems of Biophotonics,2009