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I study cellular decision making and population biology, specifically targeting unanswered questions in haematopoietic stem cell and cancer biology.
In 2009 I graduated with a first class BSc degree from the University of Edinburgh in Mathematical Physics. In 2010 I completed the MSc degree in Bioinformatics and Theoretical Systems Biology at Imperial College London, graduating with distinction.
During my PhD research I am developing spatio-temporal dynamical models that enable the elucidation of aspects of stem cell behaviour, such as control over cell fate choices and competition within the stem cell niche. New statistical methods are required in order to deal with high dimensional parameter spaces and characterise model behaviours globally in solution space.
I am especially interested in the competition between healthy haematopoietic stem cells and cancer stem cells. I seek new ways to combat leukaemia by understanding the mechanisms that underly the spread of the disease. More generally, I am using a systems biology approach to learn more about the dynamics of cancer, by framing the question as one of cellular decision making amongst competing cell species.
Population dynamics of normal and leukaemia stem cells in the haematopoietic stem cell niche show distinct regimes where leukaemia will be controlled
MacLean AL, Lo Celso C, Stumpf, MPH
J R Soc Interface, 2013. 10: 20120968. http://dx.doi.org/10.1098/rsif.2012.0968
“Population dynamics of normal and leukaemia stem cells in the haematopoietic stem cell niche”
MASAMB (Mathematical and Statistical Aspects of Molecular Biology)
Berlin, Germany, April 2012.
“The effects of hematopoietic stem cell niche dynamics on chronic myeloid leukemia”
Systems Biology of Stem Cells
University of California Irvine, USA, June 2013.
“Dynamics of haematopoiesis: strategies for eradicating leukaemia from the niche”
International Congress on Stem Cells and Tissue Formation
Dresden, Germany, July 2012.
“Population dynamics of healthy and leukaemia stem cells in the haematopoietic stem cell niche”
JST/BBSRC Molecular Imaging and Systems Biology
Tokyo, Japan, January 2012.
“Modelling the haematopoietic stem cell niche with simple dynamical models of competition”
ENFIN Enabling Systems Biology
UCL, London, UK, April 2011.